MOTS-C
MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a mitochondrial-derived peptide being heavily studied for its role in regulating metabolism, enhancing insulin sensitivity, and promoting longevity. Research focuses on its potential to reverse age- and diet-dependent insulin resistance, combat obesity, improve physical performance/exercise capacity, and reduce age-related metabolic decline.
Key areas of study for MOTS-c include:
- Metabolic Disease and Diabetes: MOTS-c increases glucose clearance, acts as an exercise-induced hormone, and has shown promise in reducing obesity and insulin resistance in high-fat diet mouse models.
- Aging and Longevity: Studies indicate MOTS-c levels decline with age and that supplementation can restore metabolic homeostasis and protect against age-related decline.
- Physical Performance and Muscle Function: Research has shown that MOTS-c treatment can double running capacity in mice and enhance skeletal muscle metabolism. It is being investigated to increase muscle mass and exercise capacity.
- Cardiovascular Protection: Studies suggest MOTS-c protects against coronary endothelial cell dysfunction by reducing oxidative stress and inhibiting inflammation.
- Bone Metabolism: Research has shown it promotes osteogenic differentiation and protects bone mass.
- Neuroprotection: Research shows MOTS-c may reduce neuroinflammation, improve memory recognition, and combat memory deficits.
